Nobel Prize Series: Chemistry 2020

All About CRISPR

The Science Behind It All

Designed by author. 3D design from 3D Molecular Designs.
Designed by author. 3D design from 3D Molecular Designs.

PAM What?

  1. Ensure the Cas9 complex doesn’t cut and destroy the viral DNA intentionally placed in the CRISPR section of the bacterial DNA
  2. Speed up the “scanning” of DNA, since the complex only needs to check for the PAM sequence and if it matches, then it will go through the trouble of unwinding the DNA and seeing if it matches fully with the gRNA

How Do Things Differ When Using CRISPR for Gene Editing

Are There Any Drawbacks?

Applications Galore

Normal red blood cells have a characteristic round shape while sickle cells have a crescent shape. Image from Optum.

Time to Test Your Knowledge!

About the Author

Sources

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